Endocrinology and Metabolism

Original Article

Clinical Study
Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study: Min Ji Jeon, Won Gu Kim, Tae Hyuk Kim, Hee Kyung Kim, Bo Hyun Kim, Hyon-Seung Yi, Eun Sook Kim, Hosu Kim, Young Nam Kim, Eun Heui Kim, Tae Yong Kim, Sun Wook Kim, Ho-Cheol Kang, Jae Hoon Chung, Young Kee Shong, Won Bae Kim; Endocrinol Metab. 2017;32(4):434-441. Published online November 22, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.4.434

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Abstract PDF Supplementary Material PubReader

Background

Little is known regarding disease-specific mortality of differentiated thyroid cancer (DTC) patients and its risk factors in Korea.

Methods

We retrospectively reviewed a large multi-center cohort of thyroid cancer from six Korean hospitals and included 8,058 DTC patients who underwent initial surgery between 1996 and 2005.

Results

Mean age of patients at diagnosis was 46.2±12.3 years; 87% were females. Most patients had papillary thyroid cancer (PTC; 97%) and underwent total thyroidectomy (85%). Mean size of the primary tumor was 1.6±1.0 cm. Approximately 40% of patients had cervical lymph node (LN) metastases and 1.3% had synchronous distant metastases. During 11.3 years of follow-up, 150 disease-specific mortalities (1.9%) occurred; the 10-year disease-specific survival (DSS) rate was 98%. According to the year of diagnosis, the number of disease-specific mortality was not different. However, the rate of disease-specific mortality decreased during the study period (from 7.7% to 0.7%). Older age (≥45 years) at diagnosis, male, follicular thyroid cancer (FTC) versus PTC, larger tumor size (>2 cm), presence of extrathyroidal extension (ETE), lateral cervical LN metastasis, distant metastasis and tumor node metastasis (TNM) stage were independent risk factors of disease-specific mortality of DTC patients.

Conclusion

The rate of disease-specific mortality of Korean DTC patients was 1.9%; the 10-year DSS rate was 98% during 1996 to 2005. Older age at diagnosis, male, FTC, larger tumor size, presence of ETE, lateral cervical LN metastasis, distant metastasis, and TNM stages were significant risk factors of disease-specific mortality of Korean DTC patients.

Citations

Citations to this article as recorded by

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Case Report

A Case of Ioslated TSH Deficiency.: Hyun Kim, Won Seob Kim, Soo Jin Choi, Dong Yoon Kim, Se Hyun Kim, Seung Min Park, Wan Koo Lee, Young Nam Kim; J Korean Endocr Soc. 1999;14(2):392-395. Published online January 1, 2001

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Abstract PDF: Although complete or partial deficiency of anterior pituitary hormone is well known,but isolated TSH deficiency is relatively rare throughout the world. Hypothyroidism due to isolated TSH deficiency is diagnosed by 1)symptoms or signs of thyroid deficiency, 2)demonstration of an absent or impaired TSH response to TRH stimulation, 3)intact other pituitary hormones. We report a case of hypothyroidism due to isolated TSH deficiency. The patient was 75 years old man and his complaints were generalized edema and weight gain. On laboratory study, T3, T4, TSH was low and TSH response to TRH stimulation was blunted, but other piutuitary hormones were intact. After thyroxine replacement, TFT and his symptoms were recovered.

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